A study on middle-aged mice exposed to 1950 MHz electromagnetic fields for 8 months found significant increases in markers for protein and lipid oxidative damage in the brains of aged mice. Despite these findings, long-term RF-EMF exposure did not change the levels of oxidative stress, DNA damage, apoptosis, astrocyte, or microglia markers in the aged mouse brains, nor did it alter locomotor activity, suggesting that long-term RF-EMF exposure did not influence age-induced oxidative stress or neuroinflammation in this context.